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教育與研究經(jīng)歷

1986.9.－1989.7.  重慶鋼鐵專科學(xué)校化學(xué)系學(xué)習(xí)

1993.9.－1995.7.  華中理工大學(xué)化學(xué)系攻讀碩士學(xué)位

1995.9.－1998.11. 華中理工大學(xué)藥物研究所攻讀博士學(xué)位

1998.11.－2000.5. 華中理工大學(xué)化學(xué)系講師

2000.6.－2001.8.  華中科技大學(xué)化學(xué)系副教授

2001.9－2002.8.   Department of Integrative Biology & Pharmacology, The University of Texas, Medical School at Houston 訪問學(xué)者

2002.9.－2004.10. 華中科技大學(xué)化學(xué)系副教授

2004.11－現(xiàn)在    華中科技大學(xué)化學(xué)系教授、博士生導(dǎo)師

研究領(lǐng)域與興趣

有氧呼吸過程中產(chǎn)生的活性氧，在病理?xiàng)l件下所致的氧化還原調(diào)控失衡，以及病理?xiàng)l件下過量產(chǎn)生的一氧化氮及其代謝過程中形成其他形式的活性氮，是導(dǎo)致衰老、神經(jīng)退行性疾病、糖尿病和炎癥炎等的重要因素。在活性氧和活性氮的產(chǎn)生及其所致的機(jī)體損傷中，微量元素鐵起了重要的介導(dǎo)作用。本課題組基礎(chǔ)研究以活性氧和活性氮的生物化學(xué)為中心，涉及過渡金屬離子催化活性氧和活性氮的產(chǎn)生及蛋白質(zhì)損傷，及其以活性氧和活性氮的抑制為主的天然藥物藥理學(xué)評(píng)價(jià)，

此外，課題組還進(jìn)行一些應(yīng)用研究，目前在硅酸鹽濕法分解技術(shù)開發(fā)方面已經(jīng)與合作單位獲得兩項(xiàng)專利授權(quán)，并正在進(jìn)行產(chǎn)業(yè)化開發(fā)。

教學(xué)情況

主講化學(xué)院本科生《無機(jī)化學(xué)》《基礎(chǔ)化學(xué)實(shí)驗(yàn)》、醫(yī)學(xué)院五年制臨床專業(yè)《基礎(chǔ)化學(xué)》。

承擔(dān)項(xiàng)目與課題

國家自然科學(xué)基金：

蛋白質(zhì)硝化對(duì)糖尿病心血管并發(fā)癥病理過程的影響研究(No. 30300073)

鐵過載肝中的蛋白質(zhì)酪氨酸硝化及黃芩苷的干預(yù)作用研究(No. 30670481)

Ab-鐵卟啉復(fù)合物催化神經(jīng)系統(tǒng)蛋白質(zhì)酪氨酸硝化修飾的反應(yīng)特性與生理影響(No. 31170808)

學(xué)術(shù)兼職

中國生物物理學(xué)會(huì)自由基專業(yè)委員會(huì)委員

中國活性氧生物學(xué)效應(yīng)專業(yè)委員會(huì)委員

武漢市微量元素與健康研究會(huì)理事長

代表性成果

1. Yi Huang, Youxia Shuai, Hailing Li, Zhonghong Gao^!*. Tyrosine residues play an important role in heme detoxification by serum albumin. Biochimica et Biophysica Acta-General Subjects. 2014, 1840(3):970-6
2. Can Yuan, Zhonghong Gao^!*. Abinteracts with both the iron center and the porphyrin ring of heme: mechanism of heme’s action on Abaggregation and disaggregation. Chemical Research in Toxicology. 2013, 26(2):262-9. 
3. Min Tu, Hayder A. Abbood, Zhening Zhu, Hailing Li, Zhonghong Gao^!*. Investigation of the photocatalytic effect of zinc oxide nanoparticles in the presence of nitrite. Journal of Hazardous Materials. 2013, 244-245: 311-321.
4. Min Tu, Yi Huang, Hailing Li, Zhonghong Gao^!*. The stress caused by nitrite with titanium dioxide nanoparticles under UVA irradiation in human keratinocyte cell. Toxicology. 2012, 299: 60-68.
5. Can Yuan, Lian Yi, Zhen Yang, Qingqing Deng, Yi Huang, Hailing Li, Zhonghong Gao^!*. Amyloid-beta-heme peroxidase promoted protein nitrotyrosination: relevance to widespread protein nitration in Alzheimer’s disease. Journal of Biological Inorganic Chemistry. 2012, 17(2):197-207.
6. Naihao Lu, Yan Zhang, Hailing Li, Zhonghong Gao ^!*. Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic rats. Free Radical Biology & Medicine. 2010 48(7):873-881
7. Yan Zhang, Naihao Lu, Zhonghong Gao^!*. Hemin-H2O2-NO2- induced protein oxidation and tyrosine nitration is different from that of SIN-1: A study on glutamate dehydrogenase nitrative/oxidative modification. International Journal of Biochemistry and Cell Biology. 2009, 41(4):907-15.
8. Naihao Lu, Zhening Zhu, Xuqi Zhao, Ran Tao, Xiangliang Yang, Zhonghong Gao^!*. Nano titanium dioxide photocatalytic protein tyrosine nitration:A potential hazard of TiO2 on skin. Biochemical and Biophysical Research Communications. 2008, 370(4):675-80. 
9. Naihao Lu, Mingyi Zhang, Hailing Li, ZhonghongGao^!*, Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Chemical Research in Toxicology. 2008, 21(6), 1229–1234.
10. Yuling Zhao, Hailing Li,Zhonghong Gao^!*, Huibi Xu. Effects of dietary baicalin supplementation on iron overload induced mouse liver oxidative injury. European Journal of Pharmacology. 2005, 509(2-3): 195-200
11. Ka Bian*, Zhonghong Gao*Norman Weisbrodt and Ferid Murad. The nature of Hemin/iron–induced protein tyrosine nitration. Proceedings of the National Academy of Sciences USA. 2003, 100(10):5712-7 (* Equally contributed to this paper)
12. Zhonghong Gao, Kaixun Huang, Huibi Xu. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacological Research. 2001, 43:173-178 (cited: 134)
13. Zhonghong Gao, Kaixun Huang, Xiangliang Yang, Huibi Xu. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et Biophysica Acta, 1999, 1472(3): 643-650.(cited: 316) 

獲獎(jiǎng)與榮譽(yù)

2004年獲湖北省青年杰出人才基金

2005年入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”