報告題目：從DNA生物物理到動態DNA納米科技
報告時間：3月7日上午10:00
報告地點：化學樓一號會議室
報告人：陳曦 博士 哈佛大學 Jane Coffin Childs Postdoctoral Fellow
摘要部分：
DNA 雙螺旋結構的發現不僅揭開了遺傳學奧秘，也讓人類把DNA做為智能生物材料而進行工程改造創造了可能。近年來，結構DNA納米科技（structural DNA nanotechnology）如DNA折紙術（DNA origami）、單鏈DNA瓦（Single-stranded tile）蓬勃發展。與此同時，動態DNA納米科技（dynamic DNA nanotechnology）也發生了革命性的進展?；趩捂溔〈?/span>strand displacement）的邏輯門和信號放大器為在溶液中實現任意化學反應網絡成為可能?；谶@些技術，DNA集成電路、DNA機械控制、DNA圖像處 理等功能被相繼實現。在這次報告中，我將介紹動態DNA納米科技的理論基礎，即DNA雜交及單鏈取代的熱力學和動力學，對近來該領域的關鍵進展作出綜述， 并著重介紹我本人在DNA信號放大器和圖像處理器方面的工作。
部分發表文章：
1. Chirieleison S, Allen P, Simpson ZB, Ellington AD, Chen X*. (2013) Pattern transformation with DNA circuits. Nat Chem. 5:1000-1005
2. Chen X, Briggs N, McLain JR, Ellington AD. Stacking nonenzymatic circuits for high signal gain . Proc Natl Acad Sci U.S.A. 110 (14) : 5386- 5391
3. Li B, Chen X*, Ellington AD. (2012) Probing Spatial Organization of DNA Strands using Enzyme - free Hairpin Assembly Circuits. J Am Chem Soc. 134(34): 13918 – 13921
4. Chen X*. (2012) Expanding the rule set of DNA circuitry with associative toehold activation. J Am Chem Soc. 34(1):263-71.
5. Li B, Ellington AD, Chen X*. (2011) Rational, modular adaptation of enzyme - free DNA circuits to multiple detection methods. Nucleic Acids Res. 39(16):e110
6. Eckhoff G, Codrea V, Ellington AD, Chen X*. (2010) Beyond allostery: Catalytic regulation of a deoxyribozyme through an entropy - driven DNA amplifier. J Syst Chem. 1:13
7. Chen X, Ellington AD. (2010) Shaping up nucleic acid computation (Review). Curr Opin Biotechnol. 21(4):392- 400
8. Chen X, Ellington AD. (2009) Design Principles for Ligand- Sensing, Conformation- Switching Ribozymes. PLoS Comput Biol. 5(12):e1000620
9. Chen X, Denison L, Levy M, Ellington AD. (2009) Direct selection for ribozyme cleavage activity in cells RNA. 15(11):2035- 45
10. Chen X, Li N, Ellington AD. (2007) Ribozyme catalysis of metabolism in the RNA world. (Review) Chem Biodivers. 4(4):633 - 55.
11. Chen X, Wang Y, Liu Q, Zhang Z, Fan C, He L. (2006) Construction of molecular logic gates with a DNA- cleaving deoxyribozyme. Angew Chem Int Ed. 45(11):1759- 62
主要獲獎情況：
2012 Jane Coffin Childs Postdoctoral Fellowship
2011 Cancer Prevention Research Institute of Texas (CPRIT) Postdoctoral Fellowship
2010 CPRIT Cancer Research Fellowship
2009 Graduate School Continuing Fellowship
2008 Ravel A ward
2007 Welch Summer Fellowship
2005 Hamilton/Schoch Fellowship
2004 Dong’s East Scholarship (Only recipient department- wide)
2003 Exemplar of Merit Students (One of only 9 recipients university- wide)
2003 National Scholarship ( Only recipient department- wide)
2002 First Prize in Physics Competition ( One of only 3 recipients university - wide)
