報(bào)告題目：Dynamic DNA Structures for Information Relay Visulized by AFM
報(bào) 告 人 ：宋杰教授
報(bào)告時(shí)間：2017年12月29日（周五）上午10:00
報(bào)告地點(diǎn)：化學(xué)樓一號(hào)會(huì)議室
邀 請 人 ：吳鈺周教授
報(bào)告人簡介：
宋杰，上海交通大學(xué)電子信息與電氣工程學(xué)院儀器科學(xué)與工程系特別研究員， 在納米生物醫(yī)學(xué)工程研究所工作。于2009年蘭州大學(xué)物理專業(yè)本科畢業(yè)，2014年獲得丹麥奧胡斯大學(xué)生物物理方向博士學(xué)位。之后在丹麥奧胡斯大學(xué)和美國埃默里大學(xué)從事博士后研究。 至今，已發(fā)表文章30余篇，其中包括 Science，Nature, Nature Nano, Nature Chemistry, Nature Communication, PNAS, JACS等國際頂級(jí)期刊，現(xiàn)主持科技部重點(diǎn)專項(xiàng)課題，國家自然基金國際合作重點(diǎn)項(xiàng)目等項(xiàng)目。 課題組現(xiàn)在主要的研究方向是高分辨AFM動(dòng)態(tài)成像，單細(xì)胞操縱， DNA納米技術(shù)在生物醫(yī)學(xué)方向的應(yīng)用，以及智能診療儀器的開發(fā)。
報(bào)告摘要：
Our research interests focus on the development of advanced Atomic Force Microscopy (AFM) for biomedical analysis and manipulation. For this talk, I will give a brief introduce about the dynamic DNA structures for information relay. Now it is a very exciting time for DNA-based molecular self-assembly. Progress in the field points to a distant, but promising future that the full potential of bimolecular self-assembly may be realized. We can envision that one day artificial systems as large, and as complex as their biological counterparts will be rationally programmed and assembled. However, in spite of the rapid progress in the field of structural DNA technology, the functionality and dynamic behaviors of current massive, complex DNA structures are greatly dwarfed by naturally occurred biomolecular systems. This lack of sophisticated dynamic behaviors limits the advancement of the field. To address this problem, we developed a new concept to build large, scalable DNA structures that can go through step-by-step reversible transformation controlled by specifically designed pathways. Considering information transfer at molecular level is fundamental in many chemical reactions and biological processes (e.g. transmembrane isgnaling), we belever our study on this novel artificial DNA system will not only have impact on the field of structural DNA technology and its applications, but also help us to better understand information transfer in other chemical and biologcial systems.
