諾貝爾化學獎得主Jean-Marie Lehn教授做客第290期化苑講壇
報告題目：Perspectives in Chemistry: From Supramolecular Chemistry towards Adaptive Chemistry
報 告 人 ：Prof. Jean-Marie Lehn
報告時間：2017年10月24日（周二）上午9:30
報告地點：八號樓三樓會議室
邀 請 人 ：李濤教授
報告人簡介：
Jean-Marie Lehn became Professor of Chemistry at the Université Louis Pasteur in Strasbourg in 1970 and from 1979 to 2010 he was Professor at the Collège de France in Paris. He is presently Professor at the University of Strasbourg Institute for Advanced Study (USIAS). He shared the Nobel Prize in Chemistry in 1987 (with Donald Cram and Charles Pedersen) for his studies on the chemical basis of “molecular recognition” (i.e. the way in which a receptor molecule recognizes and selectively binds a substrate), which also plays a fundamental role in biological processes.
Over the years his work led him to the definition of a new field of chemistry, which he has proposed calling “supramolecular chemistry” as it deals with the complex entities formed by the association of two or more chemical species held together by non-covalent intermolecular forces, whereas molecular chemistry concerns the entities constructed from atoms linked by covalent bonds. Subsequently his work developed into the chemistry of self-organization processes, based on the design of "programmed" chemical systems that undergo spontaneous assembly of suitable components into well-defined supramolecular species, directed by the supramolecular processing of molecular information. More recently, the implementation of dynamic features and of selection in both molecular and supramolecular chemistry led to the development of “constitutional dynamic chemistry”, concerning entities able to undergo reorganization in response to external stimuli, thus leading to the emergence of an “adaptive and evolutive chemistry” towards a chemistry of complex matter.
Author of more than 950 scientific publications, Lehn is a member of many academies and institutions. He has received numerous international honours and awards.
報告內容：
Supramolecular chemistry is actively exploring systems undergoing self-organization, i.e. systems capable of spontaneously generating well-defined functional supramolecular architectures by self-assembly from their components, on the basis of the molecular information stored in the covalent framework of the components and read out at the supramolecular level through specific non-covalent interactional algorithms, thus behaving as programmed chemical systems.
The design of molecular information controlled, “programmed” self-organizing systems provides an original approach to engineering and processing of functional nanostructures. It offers a powerful alternative or complement to nanofabrication and to nanomanipulation for the development of nanoscience and nanotechnology.
Supramolecular chemistry is intrinsically a dynamic chemistry in view of the lability of the interactions connecting the molecular components of a supramolecular entity and the resulting ability of supramolecular species to exchange their components. The same holds for molecular chemistry when the molecular entity contains covalent bonds that may form and break reversibility, so as to allow a continuous change in constitution by reorganization and exchange of building blocks. These features define a Constitutional Dynamic Chemistry (CDC) covering both the molecular and supramolecular levels.
CDC introduces a paradigm shift with respect to constitutionally static chemistry. It takes advantage of dynamic diversity to allow variation and selection and operates on dynamic constitutional diversity in response to either internal or external factors to achieve adaptation.
CDC generates networks of dynamically interconverting constituents, constitutional dynamic networks, presenting agonistic and antagonistic relationships between their constituents that may respond to perturbations by physical stimuli or to chemical effectors.
The implementation of these concepts points to the emergence of adaptive and evolutive chemistry, towards systems of increasing complexity.
