國(guó)家納米科學(xué)中心陳春英研究員做客第257期化苑講壇
報(bào)告題目：Interaction of Living Systems with Engineered Nanoparticles between Medical Benefit and Toxicity
報(bào) 告 人 ：陳春英研究員
報(bào)告時(shí)間：2017年5月11日（周四）上午9:30
報(bào)告地點(diǎn)：化學(xué)樓二樓一號(hào)會(huì)議室
邀 請(qǐng) 人 ：高中洪教授
報(bào)告人簡(jiǎn)介：
陳春英，國(guó)家納米科學(xué)中心研究員，國(guó)家杰出青年科學(xué)基金獲得者，國(guó)家重點(diǎn)研發(fā)計(jì)劃納米科技重點(diǎn)專(zhuān)項(xiàng)首席科學(xué)家，國(guó)家自然科學(xué)基金創(chuàng)新研究群體骨干成員。1991年畢業(yè)于華中理工大學(xué)化學(xué)系，獲學(xué)士學(xué)位，1996年畢業(yè)于華中理工大學(xué)化學(xué)系，獲博士學(xué)位。長(zhǎng)期從事納米材料的生物效應(yīng)與安全性的研究，是我國(guó)該領(lǐng)域的開(kāi)拓者之一。致力于發(fā)展檢測(cè)生物體系納米材料轉(zhuǎn)化過(guò)程的創(chuàng)新方法，揭示典型納米材料的毒理學(xué)性質(zhì)及其健康效應(yīng)的作用機(jī)制，通過(guò)調(diào)控納米材料毒理學(xué)性質(zhì)實(shí)現(xiàn)其醫(yī)學(xué)應(yīng)用。
先后主持國(guó)家重點(diǎn)研發(fā)計(jì)劃納米科技重點(diǎn)專(zhuān)項(xiàng)、973項(xiàng)目課題、國(guó)家重大儀器專(zhuān)項(xiàng)課題、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目等。相關(guān)研究成果已在Nature Methods, Nature Commun, Chem Soc Rev, Accounts Chem Res, JACS, PNAS, Adv Mater, ACS Nano等國(guó)際著名學(xué)術(shù)刊物發(fā)表學(xué)術(shù)論文190余篇，他引超過(guò)6000 次。曾獲得國(guó)家自然科學(xué)二等獎(jiǎng)、中國(guó)十大青年女科學(xué)家獎(jiǎng)、入選國(guó)家百千萬(wàn)人才工程、全球高引用科學(xué)家、以及中國(guó)科學(xué)院第五屆“十大杰出婦女”等榮譽(yù)稱(chēng)號(hào)。
報(bào)告內(nèi)容：
Many nanomaterials are promising in biological detection, diagnosis, and therapy for diseases and have shown great potential for biomedical applications. It is important to obtain a better understanding of the uptake, trafficking, pharmacokinetics, clearance, and role of nanomaterials in biological systems, so that their possible undesirable effects can be avoided. Chemical speciation, dynamics and kinetics of nanomaterials in biological systems are extremely necessary since we have very limited knowledge. The intrinsic physicochemical properties of nanomaterials have decisive influence on their biological consequences. These properties include size, shape, surface charge, chemical composition, surface modification, metal impurities, agglomeration and dispersion, degradation, as well as the formation of “protein corona”. In this talk, I will summarize our recent progresses and will show how state-of-the-art approaches help us to understand the fate and behavior of nanomaterials in vivo. We will highlight the concept of safe-by-design for designing biocompatible nanomaterials with low-toxicity and high-efficacy.
